Introduction to Synthetic Biology for Scientists and Biohackers

This lab-based course will introduce synthetic and systems biology approaches and methods from a basic science perspective. The course will focus on how synthetic biology, which properly should be called “synthetic bioengineering”, to reduce complex biological systems to a set of simple modules with defined functionality that can be used to assemble ever more complex functional modules. Good engineering practice of design, build, test and repeat will be applied to prokaryotic and eukaryotic regulatory and structural components, such as those involved in transcrip More advanced students will be provided with appropriate material. The course will cover design and implementation of biological circuits and genome engineering. The concepts behind standardized parts will be introduced as well as potential limitations. Biological parts will be available from the 2013 Biobrick distribution, and new parts will be designed and synthesized as needed. New Biobrick compliant parts will be returned to the Registry. Laboratory space is fully equipped for synthetic, molecular and cell biology. Gibson and standard recombinant DNA-based assembly will be used as needed.

In this course, projects will be assigned by the instructor with the goal of producing enough data for publication of a short report in a peer-reviewed scientific journal. However, experimental results will be the determining factor as to whether this goal can be achieved.

The main instructor is an experienced biologist, biotechnologist with basic research and industry experience, who has previously supervised three IGEM teams with an interest in linking basic research on aging, regeneration and synthetic biology. Subject to interest, the course is tentatively set to meet daily for 3 weeks at Regenerative Sciences Institute, 501(c)(3) non-profit organization, located in Sunnyvale, CA near Moffett Field.  Lectures and demonstrations will be for 2-3 hours on weekdays, with the rest of the day available for lab work. Tentatively, the course will run from December 6 through December 20 and from January 3 through 10. Tuition is currently set at $3500 for instruction and supplies. A target class size of 6-8 students has been set. We will offer one scholarship and are seeking corporate sponsorship for additional scholarships. If interested please email [email protected] with the subject “Introduction to Synthetic Biology for Scientists and Biohackers.”

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