Publications

Larrick JW, Mendelsohn AR. Modulation of cGAS-STING Pathway by Nicotinamide
Riboside in Alzheimer’s Disease. Rejuvenation Res. 2021 Oct;24(5):397-402. doi:
10.1089/rej.2021.0062. PMID: 34694148.
Larrick JW, Larrick JW, Mendelsohn AR. Response to Hypoxia in Cognitive
Decline. Rejuvenation Res. 2021 Aug;24(4):319-324. doi: 10.1089/rej.2021.0051.
PMID: 34314252.
Larrick JW, Mendelsohn AR, Larrick JW. Beneficial Gut Microbiome Remodeled
During Intermittent Fasting in Humans. Rejuvenation Res. 2021 Jun;24(3):234-237.
doi: 10.1089/rej.2021.0025. PMID: 34039011.
Kamat SM, Mendelsohn AR, Larrick JW. Rejuvenation Through Oxygen, More or
Less. Rejuvenation Res. 2021 Apr;24(2):158-163. doi: 10.1089/rej.2021.0014.
PMID: 33784834.
Mendelsohn AR, Larrick JW. Metabolic Reprogramming Rejuvenates Aged Myeloid
Cells Restoring Cognition. Rejuvenation Res. 2021 Feb;24(1):65-67. doi:
10.1089/rej.2021.0004. PMID: 33487125.
Larrick JW, Larrick JW, Mendelsohn AR. SUMO Wrestles with Mitophagy to Extend
Lifespan. Rejuvenation Res. 2020 Dec;23(6):527-532. doi: 10.1089/rej.2020.2406.
PMID: 33256568.
Larrick JW, Larrick JW, Mendelsohn AR. Contribution of Ferroptosis to Aging
and Frailty. Rejuvenation Res. 2020 Oct;23(5):434-438. doi:
10.1089/rej.2020.2390. PMID: 32977738.
Larrick JW, Mendelsohn AR. Eosinophils and White Fat: Protection from Worms
and Inflammaging. Rejuvenation Res. 2020 Aug;23(4):349-352. doi:
10.1089/rej.2020.2375. PMID: 32718231.
Larrick JW, Mendelsohn AR. Exercise Partially Rejuvenates Muscle Stem Cells.
Rejuvenation Res. 2020 Jun;23(3):262-265. doi: 10.1089/rej.2020.2359. PMID:
32484032.
Larrick JW, Mendelsohn AR. Supplementation with Brush Border Enzyme Alkaline
Phosphatase Slows Aging. Rejuvenation Res. 2020 Apr;23(2):171-175. doi:
10.1089/rej.2020.2335. PMID: 32253980.
Mendelsohn AR, Larrick JW. The Danger of Being Too Sympathetic:
Norepinephrine in Alzheimer’s Disease and Graying of Hair. Rejuvenation Res.
2020 Feb;23(1):68-72. doi: 10.1089/rej.2020.2309. Epub 2020 Feb 11. PMID:
31989871.
Larrick JW, Mendelsohn AR. Increased REST to Optimize Life Span?
Rejuvenation Res. 2019 Dec;22(6):529-532. doi: 10.1089/rej.2019.2287. PMID:
31762373.
Mendelsohn AR, Larrick JW. Epigenetic Age Reversal by Cell-Extrinsic and
Cell-Intrinsic Means. Rejuvenation Res. 2019 Oct;22(5):439-446. doi:
10.1089/rej.2019.2271. PMID: 31578938.
Larrick JW, Mendelsohn AR. Roads to the Fountain of Youth? Rejuvenating
Intestinal Stem Cells. Rejuvenation Res. 2019 Aug;22(4):342-347. doi:
10.1089/rej.2019.2251. PMID: 31364468.
Mendelsohn AR, Larrick JW. Interacting NAD<sup>+</sup> and Cell Senescence
Pathways Complicate Antiaging Therapies. Rejuvenation Res. 2019
Jun;22(3):261-266. doi: 10.1089/rej.2019.2218. PMID: 31140365.
Larrick JW, Mendelsohn AR. Regulation of S-Nitrosylation in Aging and
Senescence. Rejuvenation Res. 2019 Apr;22(2):171-174. doi:
10.1089/rej.2019.2194. PMID: 30943847.
Mendelsohn AR, Larrick JW. Cellular Senescence as the Key Intermediate in
Tau-Mediated Neurodegeneration. Rejuvenation Res. 2018 Dec;21(6):572-579. doi:
10.1089/rej.2018.2155. PMID: 30489222.
Mendelsohn AR, Larrick JW. Prevention of Senescence in Vasculature Through
Quiescence. Rejuvenation Res. 2018 Oct;21(5):477-481. doi:
10.1089/rej.2018.2138. PMID: 30259779.
Mendelsohn AR, Larrick JW. Mitochondrial-Derived Peptides Exacerbate
Senescence. Rejuvenation Res. 2018 Aug;21(4):369-373. doi:
10.1089/rej.2018.2114. PMID: 30058454.
Larrick JW, Mendelsohn AR. Finally, a Regimen to Extend Human Life
Expectancy. Rejuvenation Res. 2018 Jun;21(3):278-282. doi:
10.1089/rej.2018.2088. PMID: 29781380.
Mendelsohn AR, Larrick JW. Telomerase May Paradoxically Accelerate Aging of
the DNA Methylome. Rejuvenation Res. 2018 Apr;21(2):168-172. doi:
10.1089/rej.2018.2073. PMID: 29667924.
Larrick JW, Larrick JW, Mendelsohn AR. ATP Synthase, a Target for Dementia
and Aging? Rejuvenation Res. 2018 Feb;21(1):61-66. doi: 10.1089/rej.2018.2056.
PMID: 29461942.
Larrick JW, Mendelsohn AR. Mesenchymal Stem Cells for Frailty? Rejuvenation
Res. 2017 Dec;20(6):525-529. doi: 10.1089/rej.2017.2042. PMID: 29179649.
Mendelsohn AR, Larrick JW. Epigenetic Drift Is a Determinant of Mammalian
Lifespan. Rejuvenation Res. 2017 Oct;20(5):430-436. doi: 10.1089/rej.2017.2024.
PMID: 28942711.
Mendelsohn AR, Larrick JW. Inflammation, Stem Cells, and the Aging
Hypothalamus. Rejuvenation Res. 2017 Aug;20(4):346-349. doi:
10.1089/rej.2017.2002. PMID: 28756738.
Mendelsohn AR, Larrick JW. The NAD+/PARP1/SIRT1 Axis in Aging. Rejuvenation
Res. 2017 Jun;20(3):244-247. doi: 10.1089/rej.2017.1980. PMID: 28537485.
Li B, Xu L, Tao F, Xie K, Wu Z, Li Y, Li J, Chen K, Pi C, Mendelsohn A, Larrick JW, Gu H, Fang J. Simultaneous exposure to Fc?R and Fc?R on monocytes and macrophages enhances antitumor activity in vivo. Oncotarget. 2017 Jun 13;8(24):39356-39366. doi: 10.18632/oncotarget.17000. PMID: 28454118; PMCID: PMC5503618.
Nguyen V, Mendelsohn A, Larrick JW. Interleukin-7 and Immunosenescence. J Immunol Res. 2017;2017:4807853. doi: 10.1155/2017/4807853. Epub 2017 Apr 6. PMID: 28484723; PMCID: PMC5397725.
Mendelsohn AR, Larrick JW, Lei JL. Rejuvenation by Partial Reprogramming of
the Epigenome. Rejuvenation Res. 2017 Apr;20(2):146-150. doi:
10.1089/rej.2017.1958. PMID: 28314379.
Mendelsohn AR, Larrick JW. Pharmaceutical Rejuvenation of Age-Associated
Decline in Spatial Memory. Rejuvenation Res. 2016 Dec;19(6):521-524. doi:
10.1089/rej.2016.1903. PMID: 27881050.
Larrick JW, Larrick JW, Mendelsohn AR. Reversal of Aged Muscle Stem Cell
Dysfunction. Rejuvenation Res. 2016 Oct;19(5):423-429. doi:
10.1089/rej.2016.1875. Epub 2016 Oct 11. PMID: 27612523.
Larrick JW, Larrick JW, Mendelsohn AR. Uncoupling Mitochondrial Respiration
for Diabesity. Rejuvenation Res. 2016 Aug;19(4):337-40. doi:
10.1089/rej.2016.1859. PMID: 27378359.
Mendelsohn AR, Larrick JW. Preclinical Reversal of Atherosclerosis by FDA-
Approved Compound that Transforms Cholesterol into an Anti-Inflammatory
“Prodrug”. Rejuvenation Res. 2016 Jun;19(3):252-5. doi: 10.1089/rej.2016.1849.
PMID: 27241174.
Mendelsohn AR, Larrick JW. Rejuvenating Muscle Stem Cell Function: Restoring
Quiescence and Overcoming Senescence. Rejuvenation Res. 2016 Apr;19(2):182-6.
doi: 10.1089/rej.2016.1829. PMID: 27000748.
Mendelsohn AR, Larrick JW. Thymus Maintenance and Regeneration by Specific
Molecular Factors. Rejuvenation Res. 2016 Feb;19(1):90-3. doi:
10.1089/rej.2016.1812. Erratum in: Rejuvenation Res. 2016 Jun;19(3):270. PMID:
26837468.
Suter B, Zhang X, Pesce CG, Mendelsohn AR, Dinesh-Kumar SP, Mao JH. Next-
Generation Sequencing for Binary Protein-Protein Interactions. Front Genet. 2015
Dec 17;6:346. doi: 10.3389/fgene.2015.00346. PMID: 26734059; PMCID: PMC4681833.
Mendelsohn AR, Larrick JW. Aging Stem Cells Lose the Capability to
Distribute Damaged Proteins Asymmetrically. Rejuvenation Res. 2015
Dec;18(6):581-4. doi: 10.1089/rej.2015.1800. PMID: 26650679.
Mendelsohn AR, Larrick JW. Telomerase Reverse Transcriptase and Peroxisome
Proliferator-Activated Receptor ? Co-Activator-1? Cooperate to Protect Cells
from DNA Damage and Mitochondrial Dysfunction in Vascular Senescence.
Rejuvenation Res. 2015 Oct;18(5):479-83. doi: 10.1089/rej.2015.1780. PMID:
26414604.
Mendelsohn AR, Larrick JW. Stem Cell Depletion by Global Disorganization of
the H3K9me3 Epigenetic Marker in Aging. Rejuvenation Res. 2015 Aug;18(4):371-5.
doi: 10.1089/rej.2015.1742. PMID: 26160351.
Larrick JW, Mendelsohn AR. Telomerase redux: ready for prime time?
Rejuvenation Res. 2015 Apr;18(2):185-7. doi: 10.1089/rej.2015.1695. PMID:
25790341.
Mendelsohn AR, Lei JL, Chatterjee D. Epigenetic/Genetic Mismatch: Using
Transdifferentiation as a Potential Cancer Therapy to Exploit the Cell Type
Specificity of Cancer. Crit Rev Oncog. 2015;20(5-6):519-35. doi:
10.1615/CritRevOncog.v20.i5-6.190. PMID: 27279245.
Wang JQ, DeChalus A, Chatterjee DN, Keller ET, Mizokami A, Camussi G,
Mendelsohn AR, Renzulli Ii JF, Quesenberry PJ, Chatterjee D. Extracellular
Vesicle-Mediated Reversal of Paclitaxel Resistance in Prostate Cancer. Crit Rev
Oncog. 2015;20(5-6):407-17. doi: 10.1615/CritRevOncog.v20.i5-6.120. PMID:
27279238; PMCID: PMC5331882.
Mendelsohn AR, Larrick JW. Systemic factors mediate reversible age-
associated brain dysfunction. Rejuvenation Res. 2014 Dec;17(6):525-8. doi:
10.1089/rej.2014.1643. PMID: 25400086.
Mendelsohn AR, Larrick JW. Prolonged fasting/refeeding promotes
hematopoietic stem cell regeneration and rejuvenation. Rejuvenation Res. 2014
Aug;17(4):385-9. doi: 10.1089/rej.2014.1595. PMID: 25072352.
Mendelsohn AR, Larrick JW. Paradoxical effects of antioxidants on cancer.
Rejuvenation Res. 2014 Jun;17(3):306-11. doi: 10.1089/rej.2014.1577. PMID:
24828241.
Mendelsohn AR, Larrick JW. Partial reversal of skeletal muscle aging by
restoration of normal NAD? levels. Rejuvenation Res. 2014 Feb;17(1):62-9. doi:
10.1089/rej.2014.1546. PMID: 24410488.
Mendelsohn AR Larrick JW. 2013. Medical implications of basic research in aging. 1st edition. Palo Alto, CA: Eosynth Press.
Larrick JW, Mendelsohn A, Sharma V, Wang J, Fang J, Huang M, Wages JM, Wright SC. 2013. Trophokines: novel therapy for senescence-related fibrosis. Chapter 28 in: Inflammation, Advancing Age and Nutrition: Research and Clinical Interventions. Eds., Rahman I, Bagchi D. Elsevier/Academic Press.
Mendelsohn AR, Larrick JW. 2013. Sleep facilitates clearance of metabolites from the brain: glymphatic function in aging and neurodegenerative diseases. Rejuvenation Res. 16:518-23

Mendelsohn AR, Larrick JW.2013. Trade-offs between anti-aging dietary supplementation and exercise. Rejuvenation Res. 16:419-26
Mendelsohn AR, Larrick JW.2013. Rejuvenation of aging hearts. Rejuvenation Res. 16:330-2
Mendelsohn AR, Larrick JW.2013. Rejuvenation of adult stem cells: is age-associated dysfunction epigenetic? Rejuvenation Res. 16:241-4
Mendelsohn AR, Larrick JW.2013. Rejuvenation of adult stem cells: is age-associated dysfunction epigenetic? Rejuvenation Res. 16:152-7
Mendelsohn AR, Larrick JW. 2013. The DNA methylome as a biomarker for epigenetic instability and human aging. Rejuvenation Res. 16:74-7
1.Larrick JW. 2012. Progress with promising human antibodies. Immunotherapy 4:1-5.
Mendelsohn AR, Larrick JW. 2012. Fibroblast growth factor-21 is a promising dietary restriction mimetic. Rejuvenation Res. 15:624-8
Lamdan H, Gavilondo JV, Muñoz Y, Pupo A, Huerta V, Musacchio A, Pérez L, Ayala M, Rojas G, Balint RF, Larrick JW. 2013. Affinity maturation and fine functional mapping of an antibody fragment against a novel neutralizing epitope on human vascular endothelial growth factor. Mol Biosyst. 9:2097-106
Mendelsohn AR, Larrick JW. 2012. Dietary restriction: critical co-factors to separate health span from life span benefits. Rejuvenation Res. 15:523-9
Mendelsohn AR, Larrick JW. 2012. Ectopic expression of telomerase safely increases health span and life span. Rejuvenation Res. 15:435-8
Mendelsohn AR, Larrick JW. 2012. Dissecting mammalian target of rapamycin to promote longevity. Rejuvenation Res. 15:334-7
Mendelsohn AR, Larrick JW. 2012. Epigenetic-mediated decline in synaptic plasticity during aging. Rejuvenation Res. 15:98-101
Mendelsohn AR, Larrick JW. 2011. Overcoming the aging systemic milieu to restore neural stem cell function. Rejuvenation Res. 14:681-4
Mendelsohn AR, Larrick JW. 2011. Reversing age-related decline in working memory. Rejuvenation Res. 14:557-9
Mendelsohn AR, Larrick JW. 2011. Rapamycin as an antiaging therapeutic?: targeting mammalian target of rapamycin to treat Hutchinson-Gilford progeria and neurodegenerative diseases. Rejuvenation Res. 14:437-41
Mendelsohn AR, Larrick JW. 2011. Medical implications of basic science: protein homeostasis as a clinical target for increased longevity? Rejuvenation Res. 14:335-9
Mendelsohn AR, Larrick JW. 2011. Master switch of mitochondrial biogenesis: a clinical target for health span enhancement? 14:223-6
Mendelsohn AR, Larrick JW. 2010. Applied Healthspan engineering. Rejuvenation Res. 13:265-80
Chan CK, Liao S, Li B, Lareu RR, Larrick JW, Ramakrishna S, Raghunath M. 2009. Early adhesive behavior of bone-marrow-derived mesenchymal stem cells on collagen electrospun fibers. Biomed Mater 4:350-6.
Wang Y, Jiang J, Jiang X, Cai S, Han H, Li L, Tian Z, Jiang W, Zhang Z, Xiao Y, Wright SC, Larrick JW. 2008. Synthesis and antitumor activity evaluations of albumin-binding prodrugs of CC-1065 analog. Bioorg Med Chem 16:6552-9.
Lee RJ, Fang Q, Davol, PA, Gu Y, Sievers RE, Grabert RC, Gall, JM, Yee MS, Fok,H, Huang NF, Padbury JF, Larrick JW, Lum JG. 2007. Antibody Targeting of Stem Cells to Infarcted Myocardium. Stem Cells 25:712-7
Mendelsohn AR. 2004. Interaction trap/two-hybrid system to identify loss-of-interaction mutant proteins. Curr Protoc Mol Biol.
Pearson AM, Baksa K, Rämet M, Protas M, McKee M, Brown D, Ezekowitz RA. 2003. Identification of cytoskeletal regulatory proteins required for efficient phagocytosis in Drosophila. Microbes Infect. 5:815-24.
Rämet M, Pearson A, Baksa K, and Harikrishnan A. “Pattern Recognition Receptors in Drosophila” in Innate Immunity ed. Alan Ezekowitz and Jules Hoffman 2003 Humana Press.
Mendelsohn AR. 2002. An enlightened genetic switch. Nat Biotechnol. 20:985-7
Mendelsohn AR, Hamer JD, Wang ZB, Brent R. 2002. Cyclin D3 activates Caspase 2, connecting cell proliferation with cell death. Proc Natl Acad Sci U S A. 99:6871-6
Baksa K, Parke T, Dobens LL, Dearolf CR. 2002. The Drosophila STAT protein, stat92E, regulates follicle cell differentiation during oogenesis. Dev Biol. 243:166-75.
Oh J, Baksa K, Steward R. Functional domains of the Drosophila bicaudal-D protein. Genetics. 2000 154:713-24.
Mendelsohn AR, Brent R. 1999. Protein interaction methods–toward an endgame. Science. 284:1948-50
Mendelsohn AR, Brent R. 1998. Postgenomic protein analysis: the next bend in the river. Nat Biotechnol. 16:520-1.
Xu CW, Mendelsohn AR, Brent R. 1997. Cells that register logical relationships among proteins. Proc Natl Acad Sci U S A. 94:12473-8
Mendelsohn AR, Brent R. 1994. Applications of interaction traps/two-hybrid systems to biotechnology research. Curr Opin Biotechnol. 5:482-6
Baksa K, Morawietz H, Dombrádi V, Axton M, Taubert H, Szabó G, Török I, Udvardy A, Gyurkovics H, Szöör B, et al. 1993. Mutations in the protein phosphatase 1 gene at 87B can differentially affect suppression of position-effect variegation and mitosis in Drosophila melanogaster. Genetics. 135:117-25.
Mendelsohn AR, Coleman JR.1992. Simple, rapid, reversible staining of nucleic acid immobilized on blots. Biotechniques. 12:379.
Chatterjee D, Mendelsohn A, Shank PR, Savarese TM. 1989. Reversible suppression of c-myc expression in a human colon carcinoma line by the anticancer agent N-methylformamide. Cancer Res. 49:3910-6

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