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Medical Implications of Basic Research in Aging

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Regenerative Science @regensci·
18 Aug 2020

First-in-class senolytic drug UBX0101 that breaks p53/MDM2 interaction has failed in a clinical trail to relieve pain in osteoarthritis. Are senolytics more effective in mice than men? Perhaps needs to be combined with an anti-inflammatory drug in people. https://t.co/sKWUxm5hFs
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Regenerative Science @regensci·
14 May 2020

bioRxiv viewer https://t.co/g14EnsuBCM Rejuvenation of rats using a young blood fraction is being taken seriously. David Sinclair, [email protected], who has done extensive research on NAD+ and resveratrol wrote a series of tweets on May 11 here:
David A. Sinclair@davidasinclair
Finally had time to carefully read the new preprint that claims to reverse the age of rats by 54%. I spoke to the first author & in this thread ask whether the results are believable and what if it is true? https://t.co/Odcd24slwe 1/n
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Regenerative Science @regensci·
11 May 2020

The most impressive rejuvenation yet reported in adult mammals via a not clearly-described plasma fraction from young animals. DNA methylation clocks significantly rolled back. https://t.co/aCyVZZuLxj
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Regenerative Science @regensci·
2 Feb 2020

The era of milli/micro/nano robots is approaching: Novel living millimeter-scale machines designed by a computer engineered from frog muscle. https://t.co/pNk5RZtby6 https://t.co/Ld9CAEv8OO
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